Zelenograd, Russian Federation
Moskva, Russian Federation
Sankt-Peterburg, Russian Federation
Moskva, Russian Federation
Lomonosov Moscow State University
Moscow, Moscow, Russian Federation
Moskva, Russian Federation
Moskva, Moscow, Russian Federation
Moskovskiy gosudarstvennyy universitet imeni M.V.Lomonosova
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Vol'sk, Saratov, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Puschino, Moscow, Russian Federation
Emanuel Institute of Biochemical Physics Russian Academy of Sciences
Moskva, Russian Federation
Vol'sk, Saratov, Russian Federation
Vol'sk, Saratov, Russian Federation
Moskva, Moscow, Russian Federation
Puschino, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Emanuel Institute of Biochemical Physics Russian Academy of Sciences
Moskva, Russian Federation
Moskva, Moscow, Russian Federation
Kazan', Kazan, Russian Federation
Chernogolovka, Moscow, Russian Federation
Moskva, Russian Federation
Vol'sk, Saratov, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Vol'sk, Saratov, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Lomonosov Moscow State University
Moskva, Moscow, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Puschino, Moscow, Russian Federation
Emanuel Institute of Biochemical Physics Russian Academy of Sciences
Moskva, Russian Federation
Emanuel Institute of Biochemical Physics Russian Academy of Sciences
Moskva, Russian Federation
Vol'sk, Saratov, Russian Federation
Moskva, Moscow, Russian Federation
Russian Federation
Vol'sk, Saratov, Russian Federation
Puschino, Moscow, Russian Federation
Puschino, Moscow, Russian Federation
VAC 03.01.2002 Биофизика
VAC 03.01.2004 Биохимия
VAC 03.01.2006 Биотехнология (в том числе бионанотехнологии)
UDK 51 Математика
UDK 54 Химия. Кристаллография. Минералогия. Минераловедение
UDK 57 Биологические науки
UDK 61 Медицина. Охрана здоровья
UDK 63 Сельское хозяйство. Лесное хозяйство. Охота. Рыбное хозяйство
UDK 66 Химическая технология. Химическая промышленность. Родственные отрасли
GRNTI 31.21 Органическая химия
GRNTI 31.23 Биоорганическая химия. Природные органические соединения и их синтетические аналоги
GRNTI 31.27 Биологическая химия
GRNTI 34.17 Биофизика
GRNTI 34.35 Экология
GRNTI 34.47 Токсикология
OKSO 04.03.01 Химия
OKSO 04.07.01 Химические науки
OKSO 06.07.01 Биологические науки
OKSO 18.03.01 Химическая технология
BBK 24 Химические науки
BBK 242 Органическая химия
BBK 28 Биологические науки
BBK 528 Фармакология. Фармация. Токсикология
TBK 62 Химические науки
TBK 622 Органическая химия
TBK 6224 Биоорганическая химия
TBK 6242 Природные полимеры
TBK 626 Физическая химия. Химическая физика
TBK 636 Экология
TBK 64 Биологические науки
TBK 6412 Молекулярная биология. Общая морфология, биофизика, биохимия, физиология
TBK 6444 Биофизика, биохимия, физиология и экология растений
BISAC SCI010000 Biotechnology
BISAC SCI013040 Chemistry / Organic
BISAC SCI013090 Chemistry / Toxicology
BISAC SCI026000 Environmental Science (see also Chemistry / Environmental)
BISAC SCI007000 Life Sciences / Biochemistry
BISAC SCI009000 Life Sciences / Biophysics
BISAC SCI020000 Life Sciences / Ecology
The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.
organophosphorus compounds, kinetic model, dynamics of the process, the human brain, inhibition of acetylcholinesterase, acetylcholine, neuromuscular contraction, cholinergic synapse, synaptic cleft, degradation, immobilized enzymes, environmental safety, hydrolases, oxidoreductases, C-P-bound, cholinesterase, phosphatase, organophosphate hydrolase, catalysis mechanism, active center, metal ions, computer modeling, self-detoxification, composite protective materials, microbial biodegradation
Authors Zlobin Alexander , Inozemcev Valeriy , Komissarenko Sergey , Medveckiy Igor , Nelga Igor , Tretyakov Sergey , Sherstyuk Artem
2. Research on cholinesterases in the Soviet Union and Russia
Authors Varfolomeev Sergey , Basova Nataliya , Lushchekina Sofya , Masson Patrick , Moralev Sergey , Rozengart Evgeniy
3. Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind
Authors Gorbunov Konstantin , Gudkov Denis
4. Human cholinesterases
Authors Varfolomeev Sergey , Grigorenko Bella , Lushchekina Sofya , Masson Patrick , Mahaeva Galina , Nemuchin Alexander
5. Kinetic modelling of processes in the cholinergic synapse. Mechanisms of functioning and control methods
Authors Varfolomeev Sergey , Bykov Viktor , Tsybenova Svetlana
6. Study and modeling of mechanisms of cholinesterasis reactions in order to improve their catalytic properties in the neutralization reactions of organophosphorus compounds
Authors Varfolomeev Sergey , Grigorenko Bella , Lushchekina Sofya , Masson Patrick , Mahaeva Galina , Novichkova Dana , Nemuchin Alexander
7. Enzymatic detection of organophosphorus compounds
Authors Efremenko Elena , Lyagin Il'ya
8. Bioanalytical systems based on cholinesterases for detection of organophosphates
Authors Eremenko Arkadiy , Kurochkin Il'ya , Nechaeva Nataliya
9. Immunochemical methods for detection of organophosphorus compounds
Authors Eremin Sergey
10. Enzymes for detoxification of organophosphorus compounds: diversity and functions
Authors Efremenko Elena , Lyagin Il'ya
11. Catabolism of organophosphonates: biochemistry, physiology and interactions of degrading bacteria in the environment
Authors Ermakova Inna , Leontievsky Alexey , Sviridov Alexey , Shushkova Tatyana , Epiktetov Dmitriy
12. Microbial biocatalysts in the biocatalytic processes of the degradation of organophosphorus compounds
Authors Maslova Olga , Efremenko Elena , Mahlis Tat'yana , Sen'ko Ol'ga , Stepanov Nikolay , Andriyanova Mariya
13. Self-defending (self-degasing) materials for protection against organophosphorus compounds
Authors Efremenko Elena , Lyagin Il'ya , Gorelenkov Valentin , Zavialov Vasiliy , Zavialova Nataliya , Frolov George
14. Immobilized enzymatic biocatalysts and their application for destruction of organophosphorus compounds in water, soil and air systems
Authors Maslova Olga , Efremenko Elena , Lyagin Il'ya , Sen'ko Ol'ga , Aslanli Aslanli
15. Enzyme-based nanocomplexes and their construction for detoxification of organophosphorus compounds
Authors Efremenko Elena , Lyagin Il'ya , Aslanli Aslanli
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