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Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences#1$aEfremenko, Elena Nikolaevna$aLomonosov Moscow State University#1$aInozemcev, Valeriy Alexandrovich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aKomissarenko, Sergey Anatol'evich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aKurochkin, Il'ya Nikolaevich$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aLeontievsky, Alexey Arkad'evich$aG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences#1$aLushchekina, Sofya Vladimirovna$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aLyagin, Il'ya Vladimirovich$aLomonosov Moscow State University#1$aMaslova, Olga Vasil'evna$aLomonosov Moscow State University#1$aMasson, Patrick Ivon Moris$aKazan Federal University#1$aMahaeva, Galina Fayvelevna$aInstitute of Physiologically Active Substances Russian Academy of Sciences#1$aMahlis, Tat'yana Abramovna$aLomonosov Moscow State University#1$aMedveckiy, Igor Viktorovich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aMoralev, Sergey Nikolaevich$aSechenov Institute of Evolutionary Physiology and Biochemistry, RAS#1$aNelga, Igor Alikovich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aNechaeva, Nataliya Leonidovna$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aNovichkova, Dana Alexandrovna$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aNemuchin, Alexander Vladimirivich$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aRozengart, Evgeniy Viktorovich$aSechenov Institute of Evolutionary Physiology and Biochemistry, RAS#1$aSviridov, Alexey Vladimirivich$aG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences#1$aSen'ko, Ol'ga Vital'evna$aLomonosov Moscow State University#1$aStepanov, Nikolay Alekseevich$aLomonosov Moscow State University#1$aTretyakov, Sergey Vadimovich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aFrolov, George Alexandrovich$aInstitute of Steel and Alloys#1$aTsybenova, Svetlana Batozhargalovna$aEmanuel Institute of Biochemical Physics Russian Academy of Sciences#1$aSherstyuk, Artem Valer'evich$aFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation#1$aShushkova, Tatyana Valentinovna$aG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences#1$aEpiktetov, Dmitriy Olegovich$aG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences00$aORGANOPHOSPHORUS NEUROTOXINS$cMonography1#$aMoscow$bPublishing Center RIOR$c2020##$a380 p.##$aThe collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.$aorganophosphorus compounds, kinetic model, dynamics of the process, the human brain, inhibition of acetylcholinesterase, acetylcholine, neuromuscular contraction, cholinergic synapse, synaptic cleft, degradation, immobilized enzymes, environmental safety, hydrolases, oxidoreductases, C-P-bound, cholinesterase, phosphatase, organophosphate hydrolase, catalysis mechanism, active center, metal ions, computer modeling, self-detoxification, composite protective materials, microbial biodegradation$a10.29039/02026-50#$aAslanli A.G., Stepanov N.A., Senko O.V., Maslova O.V., Lyagin I.V., Efremenko E.N. The hexahistidine containing organophosphorus hydrolase enzyme and bacterial cellulose based functional materials. 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