22595nam#a2201561#i#450# 1825 20241123071459.6 20200211d2020####ek#y0engy0150####ca 978-5-369-02026-5 RUS xxu Biotechnology. SCI010000 Chemistry / Organic. SCI013040 Chemistry / Toxicology. SCI013090 Environmental Science (see also Chemistry / Environmental). SCI026000 Life Sciences / Biochemistry. SCI007000 Life Sciences / Biophysics. SCI009000 Life Sciences / Ecology. SCI020000 Математика. 51 Химия. Кристаллография. Минералогия. Минераловедение. 54 Биологические науки. 57 Медицина. Охрана здоровья. 61 Сельское хозяйство. Лесное хозяйство. Охота. Рыбное хозяйство. 63 Химическая технология. Химическая промышленность. Родственные отрасли. 66 Химические науки. 24 bbk Органическая химия. 242 bbk Биологические науки. 28 bbk Фармакология. Фармация. 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Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Efremenko, Elena Nikolaevna Lomonosov Moscow State University Inozemcev, Valeriy Alexandrovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Komissarenko, Sergey Anatol'evich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Kurochkin, Il'ya Nikolaevich Emanuel Institute of Biochemical Physics Russian Academy of Sciences Leontievsky, Alexey Arkad'evich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Lushchekina, Sofya Vladimirovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Lyagin, Il'ya Vladimirovich Lomonosov Moscow State University Maslova, Olga Vasil'evna Lomonosov Moscow State University Masson, Patrick Ivon Moris Kazan Federal University Mahaeva, Galina Fayvelevna Institute of Physiologically Active Substances Russian Academy of Sciences Mahlis, Tat'yana Abramovna Lomonosov Moscow State University Medveckiy, Igor Viktorovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Moralev, Sergey Nikolaevich Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS Nelga, Igor Alikovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Nechaeva, Nataliya Leonidovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Novichkova, Dana Alexandrovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Nemuchin, Alexander Vladimirivich Emanuel Institute of Biochemical Physics Russian Academy of Sciences Rozengart, Evgeniy Viktorovich Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS Sviridov, Alexey Vladimirivich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Sen'ko, Ol'ga Vital'evna Lomonosov Moscow State University Stepanov, Nikolay Alekseevich Lomonosov Moscow State University Tretyakov, Sergey Vadimovich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Frolov, George Alexandrovich Institute of Steel and Alloys Tsybenova, Svetlana Batozhargalovna Emanuel Institute of Biochemical Physics Russian Academy of Sciences Sherstyuk, Artem Valer'evich Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defense of the Russian Federation Shushkova, Tatyana Valentinovna G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Epiktetov, Dmitriy Olegovich G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences ORGANOPHOSPHORUS NEUROTOXINS Monography Moscow Publishing Center RIOR 2020 380 p. The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine. organophosphorus compounds, kinetic model, dynamics of the process, the human brain, inhibition of acetylcholinesterase, acetylcholine, neuromuscular contraction, cholinergic synapse, synaptic cleft, degradation, immobilized enzymes, environmental safety, hydrolases, oxidoreductases, C-P-bound, cholinesterase, phosphatase, organophosphate hydrolase, catalysis mechanism, active center, metal ions, computer modeling, self-detoxification, composite protective materials, microbial biodegradation 10.29039/02026-5 Aslanli A.G., Stepanov N.A., Senko O.V., Maslova O.V., Lyagin I.V., Efremenko E.N. The hexahistidine containing organophosphorus hydrolase enzyme and bacterial cellulose based functional materials. In IOP Conference Series: Materials Science and Engineering, 2019, 525 (1). P. 012005. IOP Publishing. Aslanly A.G., Maslova O.V., Sen'ko O.V., Efremenko E.N. Polifunkcional'nyy fermentnyy biopreparat na osnove geksagistidinsoderzhaschey organofosfatgidrolazy, deystvuyuschiy protiv bakterioza rasteniy. Vestnik biotehnologii i fiziko-himicheskoy biologii imeni Yu.A. Ovchinnikova, 2017, 13. S. 13-17. Aslanli A., Lyagin I., Efremenko E. Charges' interaction in polyelectrolyte (nano)complexing of His6-OPH with peptides: unpredictable results due to imperfect or useless concept? Int. J. Biol. Macromol., 2019, 140. Pp. 368–376. Boroduleva A.Y., Wu J., Yang Q., Li H., Zhang Q., Li P., Eremin. S.A. Development of fluorescence polarization immunoassays for parallel detection of pesticides carbaryl and triazophos in wheat grains. Anal. Methods, 2017, 9 (48). Pp. 6814–6822. Bravaya K.B., Bochenkova A.V., Grigorenko B.L., Topol I.A., Burt S.K., Nemukhin A.V. Molecular modeling the reaction mechanism of serine-carboxyl peptidases. J. Chem. Theory Comput., 2006, 2. Pp. 1168–1175. Carletti E.N., Colletier J.-P., Dupeux F., Trovaslet M., Masson P., Nachon F. Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. J Med Chem, 2010, 53. Pp. 4002–4008. Grigorenko B.L., Novichkova D.A., Lushchekina S.V., Zueva I.V., Schopfer L.M., Nemukhin A.V., Varfolomeev S.D., Lockridge O., Masson P. Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad, Chem.-Biol. Interact., 2019, 306. Pp. 138–146. Gudkov D.A., Lyagin I.V., Efremenko E.N., Kabanov A.V. Effect of dimerization on the catalytic properties of native and chimeric organophosphorus hydrolase determined by molecular modeling of the enzyme structure. Russian Chemical Bulletin, 2012, 1 (2), Pp. 449–455. Gudkov D.A., Lyagin I.V., Verkhusha V.V., Efremenko E.N. Hybrid proteins with organophosphorus hydrolase activity and fluorescence of deGFP4 protein. Moscow University Chemistry Bulletin, 2011, 66 (2). Pp. 92–98. Efremenko E., Lyagin I., Gudkov D., Varfolomeyev S. Immobilized biocatalysts for detoxification of neurotoxic organophosphorous compounds. Biocatalysis and Biotransformation, 2007, 25 (2–4). Pp. 359–364. Efremenko E.N., Sen'ko O.V., Kuc V.V., Alenina K.A., Holstov A.V., Ismailov A.D. Lyuminescentnyy biokatalizator dlya opredeleniya toksikantov. Patent RF na izobretenie № 2394910, 2010. Efremenko E.N., Zav'yalova N.V., Lyagin I.V., Sen'ko O.V., Gudkov D.A., Aksenov A. V., Stepanov N.A., Sirotkina M.S., Spiricheva O.V., Ivanov R.V., Lozinskiy V.I., Varfolomeev S.D., Kondrat'ev V.B., Holstov V.I. Sposob biorazlozheniya fosfororganicheskih soedineniy v sostave reakcionnyh mass, poluchaemyh posle himicheskogo unichtozheniya veschestva tipa VX. Patent RF na izobretenie № 2408724, 2009. Eremenko A.V., Prokopkina T.A., Kasatkin V.E., Osipova T.A., Kurochkin I.N. Planarnye tiol-chuvstvitel'nye sensornye elementy dlya opredeleniya aktivnosti butirilholine¬sterazy i analiza ee ingibitorov. Vestnik Moskovskogo Universiteta. Seriya 2. Himiya, 2014, 55 (3). S. 174–179. Efremenko E.N., Lyagin I.V., Klyachko N.L., Bronich T., Zavyalova N.V., Jiang Y., Kabanov A.V. A simple and highly effective catalytic nanozyme scavenger for organophosphorus neurotoxins. J. Control. Release, 2017, 247. Pp. 175–181. Efremenko E.N., Lyagin I.V., Zav'yalov V.V., Zav'yalova N.V., Holstov V.I., Yankovskaya A.A. Razryv S-R svyazi v fosfonatah pod deystviem fermentnyh biokatalizatorov. Teoreticheskaya i prikladnaya ekologiya, 2015, 3. C. 47–54 Efremenko E.N., Lyagin I.V., Gudkov D.A., Stepanov N.A., Sen'ko O.V., Maslova O.V., Kovalev D.A., Zav'yalova N.V., Holstov V.I., Yankovskaya A.A. Kombinirovannoe primenenie fermentnogo i bakterial'nogo biokatalizatorov v processah biodestrukcii FOV i produktov ih razlozheniya. Teoreticheskaya i prikladnaya ekologiya, 2015, (3). S. 35–39. Eremenko A.V., Dontsova E.A., Nazarov A.P., Evtushenko E.G., Amitonov S.V., Savilov S.V., Martynova L.F., Lunin V.V., Kurochkin I.N. Manganese Dioxide Nanostructures as a Nov¬el Electrochemical Mediator for Thiol Sensors. Electroanalysis, 2012, 3. P. 573. Ermakova I.T., Shushkova T.V., Sviridov A.V., Zelenkova N.F., Vinokurova N.G., Baskunov B.P., Leontievsky A.A. Organophosphonates utilization by soil strains of Ochrobactrum anthropi and Achromobacter sp. Arch. Microbiol., 2017, 199(5). Pp. 665–675. Filimonov I.V., Yankovskaya A.A., Kuzhelko S.V., Zav'yalov V.V., Zav'yalova N.V., Golipad A.N., Kolesnikov D.P., Kovtun V.A., Holstov V.I., Lyagin I.V., Efremenko E.N. Issledovaniya v sfere perspektivnogo ispol'zovaniya himiko-biologicheskih i medicinskih biokataliticheskih tehnologiy v interesah Vooruzhennyh Sil. Vestnik voysk RHB zaschity, 2018, 2 (2). S. 18–50. Hua X., Eremin S.A., Liu F., Wang M. Antibody Developments and Immunoassays for Organophosphorus Chemicals: A Review. Current Organic Chemistry, 2017, 21 (26). Pp. 2640–2652. Liu Y., Liu R., Boroduleva A., Eremin S., Guo Y., Zhu G. A highly specific and sensitive fluorescence polarization immunoassay for the rapid detection of triazophos residue in agricultural products. Anal. Methods, 2016, 8 (36). Pp. 6636–6644. Lyagin I.V., Efremenko E.N., Varfolomeev S.D. Fermentnye biosensory dlya opredeleniya pesticidov. Uspehi himii, 2017, 86. Pp. 339–355. Lyagin I., Efremenko E. Theoretical evaluation of suspected enzymatic hydrolysis of Novichok agents. Catal. Commun., 2019, 120. Pp. 91–94. Lyagin I.V., Andrianova M.S., Efremenko E.N. Extensive hydrolysis of phosphonates as unexpected behaviour of the known His6-organophosphorus hydrolase. Appl. Microbiol. Biotechnol., 2016, 100. Pp. 5829–5838. Lyagin I., Efremenko E. Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action. Molecules, 2019, 24. e2362, doi: 10.3390/molecules24132362. Lushchekina S.V., Schopfer L.M., Grigorenko B.L., Nemukhin A.V., Varfolomeev S.D., Lockridge O., Masson P. Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents, Front. Pharmacol., 2018, 9. P. 211. Makhaeva G.F., Rudakova E.V., Serebryakova O.G., Aksinenko A.Y., Lushchekina S.V., Bachurin S.O., Richardson R.J. Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo, Chem.-Biol. Interact., 2016, 259 (Pt B). Pp. 332–342. Maslova O.V., Stepanov N.A., Grigoryeva A.I., Bruyako M.G., Efremenko E.N. New effective His6-OPH-containing mineral carriers pretreated by low-temperature plasma for destruction of organophosphates in different types of soil. International Journal of Pharmacy & Technology, 2016, 8. Pp. 27317–27333. Maslova O., Aslanli A., Stepanov N., Lyagin I., Efremenko E. Catalytic characteristics of new antibacterials based on hexahistidine-containing organophosphorus hydrolase. Catalysts, 2017, 7 (9). P. 271. Maslova O.V., Senko O.V., Stepanov N.A., Aslanli A.G.Q., Efremenko E.N. His6-OPH and its stabilized forms combating quorum sensing molecules of gram-negative bacteria in combination with antibiotics. Jundishapur J. Nat. Pharm. Prod., 2017, 12 (3). P. e63649. Maslova O.V., Aslanly A.G., Sen'ko O.V., Efremenko E.N. Vozmozhnosti snizheniya minimal'nyh ingibiruyuschih koncentraciy puromicina i ceftiofura pri ih sochetanii s biopreparatami na osnove His6-OPH. Vestnik Moskovskogo universiteta. Seriya 2 Himiya, 2018, 59. S. 439–444. Masson P., Nachon F., Broomfield C.A. et al. A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters. Chem. Biol. Interact., 175 (2008). Pp. 273–280. Masson P., Nachon F. Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning, J. Neurochem., 2017, 142 Suppl 2. Pp. 26–40. Mehta J., Dhaka S., Paul A.K., Dayananda S., Deep A. Organophosphate hydrolase conjugated UiO-66-NH2 MOF based highly sensitive optical detection of methyl parathion. Environ. Res., 2019, 174. Pp. 46–53. Moralev S.N., Rozengart E.V. Comparative Enzymology of Cholinesterases, IUL Biotechnology Series La Jolla, CA (2007). 484 p. Nechaeva N., Prokopkina T., Makhaeva G., Rudakova E., Boltneva N., Dishovsky C., Ere¬menko A., Kurochkin I. Quantitative butyryl¬cholinesterase activity detection by surface-en-hanced Raman spectroscopy. Sensors and Actu¬ators B., 2018, 259. Pp. 75–82. Nel'ga I.A., Medveckiy I.V., Zlobin A.V., Tre¬t'yakov S.V., Sherstyuk A.V., Kostyuchenko I.V. Himicheskoe oruzhie: istoriya issledovaniya fosfororganicheskih otravlyayuschih veschestv za rubezhom. Vestnik voysk RHB zaschity, 2019, 3 (2). S. 175–193. Nemukhin A.V., Lushchekina S.V., Bochenkova A.V., Golubeva A.A., Varfolomeev S.D. Characterization of a complete cycle of acetylcholinesterase catalysis by ab initio QM/MM modeling. J. Mol. Model., 2008, 14. Pp. 409–416. Supotnickiy M.V., Shilo N.I., Kovtun V.A. Himicheskoe oruzhie v irano-irakskoy voyne 1980–1988 godov. 1. Podgotovka Iraka k himicheskoy voyne. Vestnik voysk RHB zaschity, 2019, 1 (3). S. 40–64. Shushkova T.V., Vinokurova N.G., Baskunov B.P., Zelenkova N.F., Sviridov A.V., Ermakova I.T., Leontievsky A.A. Glyphosate acetylation as a specific trait of Achromobacter sp. Kg 16 physiology. Appl. Microbiol. Biotechnol., 2016, 100. Pp. 847–855. Senko O., Gladchenko M., Maslova O., Efremenko E. Long-term storage and use of artificially immobilized anaerobic sludge as a powerful biocatalyst for conversion of various wastes including those containing xenobiotics to biogas. Catalysts, 2019, 9. P. e326, DOI: 10.3390/catal9040326. Senko O., Stepanov N., Tyutyunov A., Sterlin S., Grinberg V., Makhlis T., Efremenko E. Intensification of organophosphorus hydrolase synthesis by using substances with gas-transport function. Appl. Sci., 2017, 7. P. e1305, DOI: 10.3390/app7121305. Senko O., Maslova O., Efremenko E. Optimization of the use of His6-OPH-based enzymatic biocatalysts for the destruction of chlorpyrifos in soil. International journal of environmental research and public health, 2017, 14 (12). P. 1438. Sviridov A.V., Shushkova T.V., Ermakova I.T., Ivanova E.V., Epiktetov D.O., Leontievsky A.A. Microbial degradation of glyphosate herbicides (Review). Appl. Biochem. Microbiol., 2015, 51 (2). Pp. 188–195. Varfolomeev S.D., Semenova N.A., Bykov V.I., Cybenova S.B. Kinetika himicheskih processov v mozge cheloveka. Modelirovanie BOLD-signala pri fMRT issledovanii. Doklady AN, 2019, 488 (2). S. 39–43. Varfolomeev S.D., Semenova N.A., Ublinskiy M.V., Bykov V.I., Tsybenova S.B. fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate. Chemical Physics Letters, 2019, 729. Pp. 84–91. Wang P., Li H., Hassan M.M., Guo Z., Zhang Z.Z., Chen Q. Fabricating an Acetylcholinesterase Modulated UCNPs-Cu2+ Fluorescence Biosensor for Ultrasensitive Detection of Organophosphorus Pesticides-Diazinon in Food. J. Agric. Food Chem., 2019, 67. Pp. 4071–4079. Zav'yalov V.V., Kuzhelko S.V., Zav'yalova N.V., Kovtun V.A., Holstov V.I., Taranchenko Yu.F., Slastilova L.M., Efremenko E.N., Sen'kilev A.P. Sovremennye napravleniya sozdaniya novyh zaschitnyh materialov i tkaney dlya sredstv individual'noy i kollektivnoy zaschity ot toksichnyh himikatov i kletok patogenov. Vestnik voysk RHB zaschity, 2019, 3 (3). S. 117–148. Zhang H., Yang S., Ruyck K.D., Beloglazova N., Eremin S.A., Saeger S.D., Zhang S., Shen J., Wang Z. Fluorescence polarization assays for chemical contaminants in food and environmental analyses. Trends in Anal. Chem., 2019, 114. Pp. 293–313. There is an electronic copy riorpub.com